Homo sapiens Gene: TTPA
Summary
InnateDB Gene IDBG-23386.4
Last Modified 2011-02-17 [Report errors or provide feedback]
Gene Symbol TTPA
Gene Name tocopherol (alpha) transfer protein
Synonyms alphaTTP; ATTP; AVED; TTP1;
Species Homo sapiens
Ensembl Gene ENSG00000137561
Encoded Proteins
tocopherol (alpha) transfer protein
Protein Structure
Entrez Gene
Summary This gene encodes a soluble protein that binds alpha-trocopherol, a form of vitamin E, with high selectivity and affinity. This protein plays an important role in regulating vitamin E levels in the body by transporting vitamin E between membrane vesicles and facilitating the secretion of vitamin E from hepatocytes to circulating lipoproteins. Mutations in this gene cause hereditary vitamin E deficiency (ataxia with vitamin E deficiency, AVED) and retinitis pigmentosa. [provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:63961112-63998612
Strand Reverse strand
Band q12.3
Transcripts
ENST00000260116 ENSP00000260116
ENST00000521138
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0008431 vitamin E binding
GO:0019842 vitamin binding
Biological Process
GO:0001890 placenta development
GO:0001892 embryonic placenta development
GO:0006629 lipid metabolic process
GO:0006810 transport
GO:0007584 response to nutrient
GO:0009268 response to pH
GO:0009636 response to toxin
GO:0032502 developmental process
GO:0042360 vitamin E metabolic process
GO:0090212 negative regulation of establishment of blood-brain barrier
Cellular Component
GO:0005770 late endosome
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt P49638
TrEMBL
UniProt Splice Variant
Entrez Gene 7274
UniGene Hs.69049
RefSeq NM_000370
HUGO 12404
OMIM 600415
CCDS CCDS6178
HPRD 02685
IMGT
EMBL AH006950 BC058000 D49488 U21938
GenPept AAA64309 AAC67490 AAH58000 BAA08449
ImmGen TTPA (murine)
RNA Seq Atlas 7274