Version 5.4
Homo sapiens Gene: FIS1
Summary
InnateDB Gene IDBG-234267.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FIS1
Gene Name fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000214253
Encoded Proteins
IDBP-33227
fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
IDBP-384200
fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
IDBP-384201
fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
IDBP-384202
fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
IDBP-589075
fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
IDBP-585047
fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The balance between fission and fusion regulates the morphology of mitochondria. TTC11 is a component of a mitochondrial complex that promotes mitochondrial fission (James et al., 2003 [PubMed 12783892]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:101239458-101252316
Strand Reverse strand
Band q22.1
Transcripts
ENST00000223136 ENSP00000223136
ENST00000449367 ENSP00000411442
ENST00000442303 ENSP00000395964
ENST00000435848 ENSP00000413500
ENST00000482199
ENST00000474120 ENSP00000442056
ENST00000463406
ENST00000473527 ENSP00000444771
ENST00000480497
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
Experimentally validated
Total 33 [view]
Protein-Protein 30 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 3 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
Biological Process
GO:0000266 mitochondrial fission
GO:0000422 mitochondrion degradation
GO:0001836 release of cytochrome c from mitochondria
GO:0006626 protein targeting to mitochondrion
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0008053 mitochondrial fusion
GO:0010821 regulation of mitochondrion organization
GO:0016559 peroxisome fission
GO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration
GO:0035584 calcium-mediated signaling using intracellular calcium source
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043653 mitochondrial fragmentation involved in apoptotic process
GO:0051260 protein homooligomerization
GO:0051561 positive regulation of mitochondrial calcium ion concentration
GO:0070584 mitochondrion morphogenesis
GO:0090141 positive regulation of mitochondrial fission
GO:0090314 positive regulation of protein targeting to membrane
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005739 mitochondrion
GO:0005777 peroxisome
GO:0005779 integral component of peroxisomal membrane
GO:0016020 membrane
GO:0031307 integral component of mitochondrial outer membrane
GO:0043234 protein complex
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_016068
HUGO
OMIM
CCDS CCDS43626
HPRD 12352
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca