InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FIS1

Summary

InnateDB Protein

IDBP-33227.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FIS1

Protein Name

fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000223136

InnateDB Gene

IDBG-234267 (FIS1)

Protein Structure

UniProt Annotation

Function

Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin- related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission. {ECO:0000269PubMed:12783892, ECO:0000269PubMed:12861026, ECO:0000269PubMed:14996942, ECO:0000269PubMed:16107562, ECO:0000269PubMed:16118244, ECO:0000269PubMed:23283981, ECO:0000269PubMed:23530241}.

Subcellular Localization

Mitochondrion outer membrane; Single-pass membrane protein. Peroxisome membrane; Single-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.

Experimentally validated
Total	33 [view]
Protein-Protein	30 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding

Biological Process

GO:0000266	mitochondrial fission
GO:0000422	mitochondrion degradation
GO:0001836	release of cytochrome c from mitochondria
GO:0006626	protein targeting to mitochondrion
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0008053	mitochondrial fusion
GO:0010821	regulation of mitochondrion organization
GO:0016559	peroxisome fission
GO:0032471	negative regulation of endoplasmic reticulum calcium ion concentration
GO:0035584	calcium-mediated signaling using intracellular calcium source
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043653	mitochondrial fragmentation involved in apoptotic process
GO:0051260	protein homooligomerization
GO:0051561	positive regulation of mitochondrial calcium ion concentration
GO:0070584	mitochondrion morphogenesis
GO:0090141	positive regulation of mitochondrial fission
GO:0090314	positive regulation of protein targeting to membrane
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005739	mitochondrion
GO:0005777	peroxisome
GO:0005779	integral component of peroxisomal membrane
GO:0016020	membrane
GO:0031307	integral component of mitochondrial outer membrane
GO:0043234	protein complex