InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CYP7B1

Summary

InnateDB Gene

IDBG-23453.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYP7B1

Gene Name

cytochrome P450, family 7, subfamily B, polypeptide 1

Synonyms

CBAS3; CP7B; SPG5A

Species

Homo sapiens

Ensembl Gene

ENSG00000172817

Encoded Proteins

IDBP-23455

cytochrome P450, family 7, subfamily B, polypeptide 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway of extrahepatic tissues, which converts cholesterol to bile acids. This enzyme likely plays a minor role in total bile acid synthesis, but may also be involved in the development of atherosclerosis, neurosteroid metabolism and sex hormone synthesis. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:64587763-64798761

Strand

Reverse strand

Band

q12.3

Transcripts

ENST00000310193	ENSP00000310721
ENST00000523954

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0008396	oxysterol 7-alpha-hydroxylase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding
GO:0033783	25-hydroxycholesterol 7alpha-hydroxylase activity

Biological Process

GO:0006699	bile acid biosynthetic process
GO:0006805	xenobiotic metabolic process
GO:0008203	cholesterol metabolic process
GO:0008206	bile acid metabolic process
GO:0008219	cell death
GO:0016125	sterol metabolic process
GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway
GO:0044281	small molecule metabolic process
GO:0050679	positive regulation of epithelial cell proliferation
GO:0055114	oxidation-reduction process
GO:0060740	prostate gland epithelium morphogenesis