Version 5.4
Homo sapiens Gene: PTPN9
Summary
InnateDB Gene IDBG-23456.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTPN9
Gene Name protein tyrosine phosphatase, non-receptor type 9
Synonyms MEG2; PTPMEG2
Species Homo sapiens
Ensembl Gene ENSG00000169410
Encoded Proteins
IDBP-23458
protein tyrosine phosphatase, non-receptor type 9
IDBP-745855
IDBP-811833
protein tyrosine phosphatase, non-receptor type 9
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain that shares a significant similarity with yeast SEC14, which is a protein that has phosphatidylinositol transfer activity and is required for protein secretion through the Golgi complex in yeast. This PTP was found to be activated by polyphosphoinositide, and is thought to be involved in signaling events regulating phagocytosis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:75463251-75579289
Strand Reverse strand
Band q24.2
Transcripts
ENST00000306726 ENSP00000303554
ENST00000564970
ENST00000568108
ENST00000563835
ENST00000561731 ENSP00000455934
ENST00000618819 ENSP00000482732
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0004726 non-membrane spanning protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0016791 phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032290
View Gene Order
ENSBTAG00000016984
Not yet available
Cross-References
SwissProt P43378
TrEMBL H3BQT6
UniProt Splice Variant
Entrez Gene 5780
UniGene Hs.445775
RefSeq NM_002833
HUGO HGNC:9661
OMIM 600768
CCDS CCDS10280
HPRD
IMGT
EMBL AC105036 AC105137 BC010863 BT007405 M83738
GenPept AAA60226 AAH10863 AAP36073
RNA Seq Atlas 5780

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca