InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CSPG4

Summary

InnateDB Gene

IDBG-23629.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CSPG4

Gene Name

chondroitin sulfate proteoglycan 4

Synonyms

HMW-MAA; MCSP; MCSPG; MEL-CSPG; MSK16; NG2

Species

Homo sapiens

Ensembl Gene

ENSG00000173546

Encoded Proteins

IDBP-23631

chondroitin sulfate proteoglycan 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

A human melanoma-associated chondroitin sulfate proteoglycan plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. CSPG4 represents an integral membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:75674322-75712848

Strand

Reverse strand

Band

q24.2

Transcripts

ENST00000308508

ENSP00000312506

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0019901	protein kinase binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0001525	angiogenesis
GO:0005975	carbohydrate metabolic process
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008283	cell proliferation
GO:0008347	glial cell migration
GO:0030203	glycosaminoglycan metabolic process
GO:0030204	chondroitin sulfate metabolic process
GO:0030206	chondroitin sulfate biosynthetic process
GO:0030207	chondroitin sulfate catabolic process
GO:0030208	dermatan sulfate biosynthetic process
GO:0035556	intracellular signal transduction
GO:0044281	small molecule metabolic process
GO:0048771	tissue remodeling
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation

Cellular Component

GO:0005576	extracellular region
GO:0005796	Golgi lumen
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0016324	apical plasma membrane
GO:0031258	lamellipodium membrane
GO:0043202	lysosomal lumen
GO:0070062	extracellular vesicular exosome