InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CSPG4

Summary

InnateDB Protein

IDBP-23631.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CSPG4

Protein Name

chondroitin sulfate proteoglycan 4

Synonyms

HMW-MAA; MCSP; MCSPG; MEL-CSPG; MSK16; NG2;

Species

Homo sapiens

Ensembl Protein

ENSP00000312506

InnateDB Gene

IDBG-23629 (CSPG4)

Protein Structure

UniProt Annotation

Function

Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N- terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin- mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades. {ECO:0000269PubMed:10587647, ECO:0000269PubMed:11278606, ECO:0000269PubMed:15210734}.

Subcellular Localization

Apical cell membrane {ECO:0000250}; Single- pass type I membrane protein {ECO:0000250}; Extracellular side {ECO:0000250}. Cell projection, lamellipodium membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}; Extracellular side {ECO:0000250}. Note=Localized at the apical plasma membrane it relocalizes to the lamellipodia of astrocytoma upon phosphorylation by PRKCA. Localizes to the retraction fibers. Localizes to the plasma membrane of oligodendrocytes (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected only in malignant melanoma cells. {ECO:0000269PubMed:8790396}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0019901	protein kinase binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0001525	angiogenesis
GO:0005975	carbohydrate metabolic process
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008283	cell proliferation
GO:0008347	glial cell migration
GO:0030203	glycosaminoglycan metabolic process
GO:0030204	chondroitin sulfate metabolic process
GO:0030206	chondroitin sulfate biosynthetic process
GO:0030207	chondroitin sulfate catabolic process
GO:0030208	dermatan sulfate biosynthetic process
GO:0035556	intracellular signal transduction
GO:0044281	small molecule metabolic process
GO:0048771	tissue remodeling
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation

Cellular Component

GO:0005576	extracellular region
GO:0005796	Golgi lumen
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0016324	apical plasma membrane
GO:0031258	lamellipodium membrane
GO:0043202	lysosomal lumen
GO:0070062	extracellular vesicular exosome