InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CCR4

Summary

InnateDB Gene

IDBG-23908.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCR4

Gene Name

chemokine (C-C motif) receptor 4

Synonyms

CC-CKR-4; CD194; ChemR13; CKR4; CMKBR4; HGCN:14099; K5-5

Species

Homo sapiens

Ensembl Gene

ENSG00000183813

Encoded Proteins

IDBP-23910

chemokine (C-C motif) receptor 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 18624303

CCR4 modulates TLR9-mediated innate immunity and signalling.

Entrez Gene

Summary

The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:32951574-32956349

Strand

Forward strand

Band

p22.3

Transcripts

ENST00000330953

ENSP00000332659

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004950	chemokine receptor activity
GO:0016493	C-C chemokine receptor activity

Biological Process

GO:0001764	neuron migration
GO:0002507	tolerance induction
GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0009314	response to radiation
GO:0009617	response to bacterium
GO:0045087	innate immune response (InnateDB)
GO:0046677	response to antibiotic
GO:0050927	positive regulation of positive chemotaxis
GO:0070098	chemokine-mediated signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0016021	integral component of membrane
GO:0043025	neuronal cell body

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000047898

View Gene Order

ENSBTAG00000034883

Not yet available

Pathways

NETPATH

REACTOME

REACT_19231

G alpha (i) signalling events pathway

REACT_15344

Chemokine receptors bind chemokines pathway

REACT_14819

Peptide ligand-binding receptors pathway

REACT_14828

Class A/1 (Rhodopsin-like receptors) pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_21340

GPCR ligand binding pathway

KEGG

hsa04060

Cytokine-cytokine receptor interaction pathway

hsa04062

Chemokine signaling pathway pathway

INOH

PID NCI

Cross-References

SwissProt

P51679

TrEMBL

A0N0Q1

UniProt Splice Variant

Entrez Gene

1233

UniGene

RefSeq

NM_005508

HUGO

HGNC:1605

OMIM

604836

CCDS

CCDS2656

HPRD

IMGT

EMBL

AB023888 AB023889 AB023890 AB023891 AB023892 AK292674 AY322539 BC069139 BC071751 BC074935 CH471055 EF064759 X85740

GenPept

AAH69139 AAH71751 AAH74935 AAP84352 ABK41942 BAA86965 BAA86966 BAA86967 BAA86968 BAA86969 BAF85363 CAA59743 EAW64440 EAW64441

RNA Seq Atlas

1233