InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CCR4

Summary

InnateDB Protein

IDBP-23910.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCR4

Protein Name

chemokine (C-C motif) receptor 4

Synonyms

CC-CKR-4; CD194; ChemR13; CKR4; CMKBR4; HGCN:14099; K5-5;

Species

Homo sapiens

Ensembl Protein

ENSP00000332659

InnateDB Gene

IDBG-23908 (CCR4)

Protein Structure

UniProt Annotation

Function

High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol- calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival. {ECO:0000269PubMed:10466728, ECO:0000269PubMed:10754297, ECO:0000269PubMed:9169480, ECO:0000269PubMed:9430724}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Predominantly expressed in the thymus, in peripheral blood leukocytes, including T-cells, mostly CD4+ cells, and basophils, and in platelets; at lower levels, in the spleen and in monocytes. Detected also in macrophages, IL-2-activated natural killer cells and skin-homing memory T-cells, mostly the ones expressing the cutaneous lymphocyte antigen (CLA). Expressed in brain microvascular and coronary artery endothelial cells. {ECO:0000269PubMed:10754297}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004950	chemokine receptor activity
GO:0016493	C-C chemokine receptor activity

Biological Process

GO:0001764	neuron migration
GO:0002507	tolerance induction
GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0009314	response to radiation
GO:0009617	response to bacterium
GO:0045087	innate immune response (InnateDB)
GO:0046677	response to antibiotic
GO:0050927	positive regulation of positive chemotaxis
GO:0070098	chemokine-mediated signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0016021	integral component of membrane
GO:0043025	neuronal cell body

Protein Structure and Domains

PDB ID

InterPro

IPR000248 Angiotensin II receptor family
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000355 Chemokine receptor family
IPR001277 CXC chemokine receptor 4
IPR002239 CC chemokine receptor 4
IPR005384 Duffy antigen/chemokine receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00241
PR00237
PR00657
PR00645
PR01109
PR01559

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P51679