Version 5.4
Homo sapiens Gene: CXCL6
Summary
InnateDB Gene IDBG-24017.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CXCL6
Gene Name chemokine (C-X-C motif) ligand 6
Synonyms CKA-3; GCP-2; GCP2; SCYB6
Species Homo sapiens
Ensembl Gene ENSG00000124875
Encoded Proteins
IDBP-24019
chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)
IDBP-480687
chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 4:73836497-73849064
Strand Forward strand
Band q13.3
Transcripts
ENST00000226317 ENSP00000226317
ENST00000515050 ENSP00000424819
ENST00000503446
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008009 chemokine activity
GO:0008201 heparin binding
Biological Process
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0042742 defense response to bacterium
GO:0060326 cell chemotaxis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_19231
G alpha (i) signalling events pathway
REACT_15344
Chemokine receptors bind chemokines pathway
REACT_14819
Peptide ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04062
Chemokine signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.164021
RefSeq NM_002993
HUGO
OMIM
CCDS CCDS3560
HPRD 00735
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca