InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CXCL6

Summary

InnateDB Protein

IDBP-24019.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CXCL6

Protein Name

chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)

Synonyms

CKA-3; GCP-2; GCP2; SCYB6;

Species

Homo sapiens

Ensembl Protein

ENSP00000226317

InnateDB Gene

IDBG-24017 (CXCL6)

Protein Structure

UniProt Annotation

Function

Chemotactic for neutrophil granulocytes. Signals through binding and activation of its receptors (CXCR1 and CXCR2). In addition to its chemotactic and angiogenic properties, it has strong antibacterial activity against Gram-positive and Gram- negative bacteria (90-fold-higher when compared to CXCL5 and CXCL7). {ECO:0000269PubMed:18443119, ECO:0000269PubMed:8399143, ECO:0000269PubMed:8423327, ECO:0000269PubMed:9057843}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008009	chemokine activity
GO:0008201	heparin binding

Biological Process

GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0042742	defense response to bacterium
GO:0060326	cell chemotaxis