InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: VDAC1

Summary

InnateDB Gene

IDBG-240337.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VDAC1

Gene Name

voltage-dependent anion channel 1

Synonyms

PORIN; VDAC-1

Species

Homo sapiens

Ensembl Gene

ENSG00000213585

Encoded Proteins

IDBP-44347

voltage-dependent anion channel 1

IDBP-240339

voltage-dependent anion channel 1

IDBP-240341

voltage-dependent anion channel 1

IDBP-376843

voltage-dependent anion channel 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondrial functions. This protein also forms channels in the plasma membrane and may be involved in transmembrane electron transport. Alternate splicing results in multiple transcript variants. Multiple pseudogenes of this gene are found on chromosomes 1, 2 3, 6, 9, 12, X and Y.[provided by RefSeq, Sep 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:133971915-134005133

Strand

Reverse strand

Band

q31.1

Transcripts

ENST00000265333	ENSP00000265333
ENST00000395047	ENSP00000378487
ENST00000395044	ENSP00000378484
ENST00000425992	ENSP00000390129
ENST00000492324
ENST00000489906
ENST00000466080

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 86 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	86 [view]
Protein-Protein	85 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008308	voltage-gated anion channel activity
GO:0015288	porin activity

Biological Process

GO:0001662	behavioral fear response
GO:0006820	anion transport
GO:0006915	apoptotic process
GO:0007268	synaptic transmission
GO:0007270	neuron-neuron synaptic transmission
GO:0007612	learning
GO:0016032	viral process
GO:0030855	epithelial cell differentiation
GO:0044070	regulation of anion transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005743	mitochondrial inner membrane
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0042645	mitochondrial nucleoid
GO:0046930	pore complex
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000020402

View Gene Order

ENSBTAG00000013113

Not yet available

Pathways

NETPATH

REACTOME

REACT_118595

Mitochondrial protein import pathway

REACT_17015

Metabolism of proteins pathway

KEGG

hsa04020

Calcium signaling pathway pathway

hsa05012

Parkinson's disease pathway

hsa05016

Huntington's disease pathway

INOH

PID NCI

Cross-References

SwissProt

P21796

TrEMBL

C9JI87

UniProt Splice Variant

Entrez Gene

7416

UniGene

Hs.709372

RefSeq

NM_003374 XM_005272075

HUGO

HGNC:12669

OMIM

604492

CCDS

CCDS4168

HPRD

05137

IMGT

EMBL

AC005200 AC008608 AC025177 AF151093 AF151094 AF151095 AF151096 AF151097 AJ250032 AJ250033 AJ250034 AJ250035 AJ250036 AJ250037 AJ250038 AJ250039 AK122953 BC008482 BC071168 BC090042 CH471062 L06132

GenPept

AAA61272 AAC24723 AAD54939 AAH08482 AAH71168 AAH90042 BAG53816 CAB58127 EAW62281 EAW62282 EAW62283 EAW62285 EAW62286

RNA Seq Atlas

7416