InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Vdac1

Summary

InnateDB Gene

IDBG-171107.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Vdac1

Gene Name

voltage-dependent anion channel 1

Synonyms

AL033343; Vdac5

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020402

Encoded Proteins

IDBP-171109

voltage-dependent anion channel 1

IDBP-171111

voltage-dependent anion channel 1

IDBP-532071

voltage-dependent anion channel 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000213585:
This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondrial functions. This protein also forms channels in the plasma membrane and may be involved in transmembrane electron transport. Alternate splicing results in multiple transcript variants. Multiple pseudogenes of this gene are found on chromosomes 1, 2 3, 6, 9, 12, X and Y.[provided by RefSeq, Sep 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:52360860-52389397

Strand

Forward strand

Band

B1.3

Transcripts

ENSMUST00000102758	ENSMUSP00000099819
ENSMUST00000020673	ENSMUSP00000020673
ENSMUST00000125694	ENSMUSP00000116919
ENSMUST00000157052
ENSMUST00000153339

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 72 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	72 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0008308	voltage-gated anion channel activity
GO:0015288	porin activity

Biological Process

GO:0001662	behavioral fear response
GO:0006820	anion transport
GO:0006915	apoptotic process
GO:0007268	synaptic transmission
GO:0007270	neuron-neuron synaptic transmission
GO:0007612	learning
GO:0030855	epithelial cell differentiation
GO:0044070	regulation of anion transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005743	mitochondrial inner membrane
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0042645	mitochondrial nucleoid
GO:0046930	pore complex
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000213585

View Gene Order

ENSBTAG00000013113

Not yet available

Pathways

NETPATH

REACTOME

REACT_247926

Metabolism of proteins pathway

REACT_199101

Mitochondrial protein import pathway

KEGG

mmu04020

Calcium signaling pathway pathway

mmu05012

Parkinson's disease pathway

mmu05016

Huntington's disease pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_118595

Mitochondrial protein import pathway

REACT_17015

Metabolism of proteins pathway

REACT_215731

Mitochondrial protein import pathway

REACT_213782

Metabolism of proteins pathway

KEGG

hsa04020

Calcium signaling pathway pathway

hsa05012

Parkinson's disease pathway

hsa05016

Huntington's disease pathway

INOH

PID NCI

Cross-References

SwissProt

Q60932

TrEMBL

F2Z471

UniProt Splice Variant

Entrez Gene

22333

UniGene

Mm.3555

RefSeq

NM_011694

OMIM

CCDS

CCDS24671

HPRD

IMGT

MGI ID

MGI:106919

MGI Symbol

Vdac1

EMBL

AK168672 AK169160 AK169282 AK169354 AK169671 AL645589 AL713864 BC092257 U30840

GenPept

AAB47777 AAH92257 BAE40522 BAE40939 BAE41040 BAE41103 BAE41292 CAI24939 CAM19812

RNA Seq Atlas

22333