Version 5.4
Homo sapiens Gene: SSPN
Summary
InnateDB Gene IDBG-24103.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SSPN
Gene Name sarcospan
Synonyms DAGA5; KRAG; NSPN; SPN1; SPN2
Species Homo sapiens
Ensembl Gene ENSG00000123096
Encoded Proteins
IDBP-24105
sarcospan (Kras oncogene-associated gene)
IDBP-370115
sarcospan (Kras oncogene-associated gene)
IDBP-598694
sarcospan (Kras oncogene-associated gene)
IDBP-585202
sarcospan (Kras oncogene-associated gene)
IDBP-583822
sarcospan (Kras oncogene-associated gene)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the dystrophin-glycoprotein complex (DGC). The DGC spans the sarcolemma and is comprised of dystrophin, syntrophin, alpha- and beta-dystroglycans and sarcoglycans. The DGC provides a structural link between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. Two alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:26121991-26299290
Strand Forward strand
Band p12.1
Transcripts
ENST00000242729 ENSP00000242729
ENST00000422622 ENSP00000396087
ENST00000538142 ENSP00000445360
ENST00000534829
ENST00000539019
ENST00000540266 ENSP00000442893
ENST00000544231
ENST00000535504 ENSP00000438801
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006936 muscle contraction
GO:0007155 cell adhesion
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016010 dystrophin-associated glycoprotein complex
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0030133 transport vesicle
GO:0042383 sarcolemma
GO:0045211 postsynaptic membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030255
View Gene Order
ENSBTAG00000000393
Not yet available
Cross-References
SwissProt Q14714
TrEMBL F5H381
UniProt Splice Variant
Entrez Gene 8082
UniGene Hs.183428 Hs.733056 Hs.733413 Hs.736914
RefSeq NM_001135823 NM_005086
HUGO HGNC:11322
OMIM 601599
CCDS CCDS44850 CCDS8707
HPRD 03359
IMGT
EMBL AC022509 AC055720 AF016028 AK092925 AL136756 BC062299 X89105
GenPept AAC61660 AAH62299 BAG52629 CAA61479 CAB66690
RNA Seq Atlas 8082

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca