InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SSPN

Summary

InnateDB Protein

IDBP-24105.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SSPN

Protein Name

sarcospan (Kras oncogene-associated gene)

Synonyms

DAGA5; KRAG; NSPN; SPN1; SPN2;

Species

Homo sapiens

Ensembl Protein

ENSP00000242729

InnateDB Gene

IDBG-24103 (SSPN)

Protein Structure

UniProt Annotation

Function

Component of the dystrophin-glycoprotein complex (DGC), a complex that spans the muscle plasma membrane and forms a link between the F-actin cytoskeleton and the extracellular matrix. Preferentially associates with the sarcoglycan subcomplex of the DGC.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell membrane, sarcolemma {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Also found in myotendinous junctions and in the postsynaptic membrane of neuromuscular junctions. {ECO:0000250}.

Disease Associations

Tissue Specificity

Isoform 1 is expressed exclusively in heart and skeletal muscle. Isoform 2 is expressed in heart, skeletal muscle, thymus, prostate, testis, ovary, small intestine, colon and spleen.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0006936	muscle contraction
GO:0007155	cell adhesion

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0016010	dystrophin-associated glycoprotein complex
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030133	transport vesicle
GO:0042383	sarcolemma
GO:0045211	postsynaptic membrane