Version 5.4
| Homo sapiens Gene: PPBP | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-24129.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | PPBP | ||||||||||||||||||
| Gene Name | pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) | ||||||||||||||||||
| Synonyms | B-TG1; Beta-TG; CTAP-III; CTAP3; CTAPIII; CXCL7; LA-PF4; LDGF; MDGF; NAP-2; PBP; SCYB7; TC1; TC2; TGB; TGB1; THBGB; THBGB1 | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000163736 | ||||||||||||||||||
| Encoded Proteins |
pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
The protein encoded by this gene is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant and activator of neutrophils. It has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells. [provided by RefSeq, May 2010] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 4:73987038-73988197 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | q13.3 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
| No orthologs found for this gene | |||||||||||||||||||
| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Platelet degranulation pathway
Response to elevated platelet cytosolic Ca2+ pathway
G alpha (i) signalling events pathway
Chemokine receptors bind chemokines pathway
Peptide ligand-binding receptors pathway
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Platelet activation, signaling and aggregation pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
Hemostasis pathway
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| KEGG |
Cytokine-cytokine receptor interaction pathway
Chemokine signaling pathway pathway
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| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | P02775 | ||||||||||||||||||
| TrEMBL | D3JV41 D3JV42 D3JV43 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 5473 | ||||||||||||||||||
| UniGene | Hs.2164 | ||||||||||||||||||
| RefSeq | NM_002704 | ||||||||||||||||||
| HUGO | HGNC:9240 | ||||||||||||||||||
| OMIM | 121010 | ||||||||||||||||||
| CCDS | CCDS3563 | ||||||||||||||||||
| HPRD | |||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AC097709 AF349466 AK312166 BC028217 CH471057 CR456805 GU320668 GU320669 GU320670 M54995 | ||||||||||||||||||
| GenPept | AAA62836 AAH28217 AAK29642 AAY41004 ADB85518 ADB85519 ADB85520 BAG35100 CAG33086 EAX05695 | ||||||||||||||||||
| RNA Seq Atlas | 5473 | ||||||||||||||||||