Version 5.4
Homo sapiens Protein: PPBP
Summary
InnateDB Protein IDBP-24131.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPBP
Protein Name pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
Synonyms B-TG1; Beta-TG; CTAP-III; CTAP3; CTAPIII; CXCL7; LA-PF4; LDGF; MDGF; NAP-2; PBP; SCYB7; TC1; TC2; TGB; TGB1; THBGB; THBGB1;
Species Homo sapiens
Ensembl Protein ENSP00000296028
InnateDB Gene IDBG-24129 (PPBP)
Protein Structure
UniProt Annotation
Function LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III(1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation. {ECO:0000269PubMed:10877842, ECO:0000269PubMed:7890771, ECO:0000269PubMed:8950790, ECO:0000269PubMed:9794434}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
Experimentally validated
Total 34 [view]
Protein-Protein 34 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005355 glucose transmembrane transporter activity
GO:0008009 chemokine activity
GO:0008083 growth factor activity
Biological Process
GO:0002523 leukocyte migration involved in inflammatory response
GO:0002576 platelet degranulation
GO:0006955 immune response
GO:0007596 blood coagulation
GO:0015758 glucose transport
GO:0030168 platelet activation
GO:0042742 defense response to bacterium
GO:0051781 positive regulation of cell division
GO:0060326 cell chemotaxis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0031093 platelet alpha granule lumen
Protein Structure and Domains
PDB ID
InterPro IPR001089 CXC chemokine
IPR001811 Chemokine interleukin-8-like domain
PFAM PF00048
PRINTS PR00437
PIRSF
SMART SM00199
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P02775
PhosphoSite PhosphoSite-P02775
TrEMBL D3JV43
UniProt Splice Variant
Entrez Gene 5473
UniGene Hs.2164
RefSeq NP_002695
HUGO HGNC:9240
OMIM 121010
CCDS CCDS3563
HPRD 07171
IMGT
EMBL AC097709 AF349466 AK312166 BC028217 CH471057 CR456805 GU320668 GU320669 GU320670 M54995
GenPept AAA62836 AAH28217 AAK29642 AAY41004 ADB85518 ADB85519 ADB85520 BAG35100 CAG33086 EAX05695

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca