Version 5.4
Homo sapiens Gene: ERV3-1
Summary
InnateDB Gene IDBG-241834.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ERV3-1
Gene Name endogenous retrovirus group 3, member 1
Synonyms envR; ERV-R; ERV3; ERVR; HERV-R; HERVR
Species Homo sapiens
Ensembl Gene ENSG00000213462
Encoded Proteins
IDBP-376612
endogenous retrovirus group 3, member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The human genome includes many retroelements including the human endogenous retroviruses (HERVs). ERV3, one of the most studied HERVs, is thought to have integrated 30 to 40 million years ago and is present in higher primates with the exception of gorillas. Taken together, the observation of genome conservation, the detection of transcript expression, and the presence of conserved ORFs is circumstantial evidence for a functional role. A functional role is also suggested by the observation that downregulation of ERV3 is reported in choriocarcinoma. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:64990809-65006743
Strand Reverse strand
Band q11.21
Transcripts
ENST00000394323 ENSP00000391594
ENST00000528878
ENST00000535538
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0019031 viral envelope
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Cross-References
SwissProt Q14264
TrEMBL
UniProt Splice Variant
Entrez Gene 2086
UniGene Hs.596334 Hs.707660
RefSeq NM_001007253
HUGO HGNC:3454
OMIM 131170
CCDS CCDS47595
HPRD 15919
IMGT
EMBL AC073210 M12140
GenPept AAA88027
RNA Seq Atlas 2086

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca