Version 5.4
Homo sapiens Protein: ERV3-1
Summary
InnateDB Protein IDBP-376612.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ERV3-1
Protein Name endogenous retrovirus group 3, member 1
Synonyms envR; ERV-R; ERV3; ERVR; HERV-R; HERVR;
Species Homo sapiens
Ensembl Protein ENSP00000391594
InnateDB Gene IDBG-241834 (ERV3-1)
Protein Structure
UniProt Annotation
Function Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its fusogenic properties. It can inhibit cell growth through decrease expression of cyclin B1 and increased expression of p21 in vitro. {ECO:0000269PubMed:10692254, ECO:0000269PubMed:14557543, ECO:0000269PubMed:7645262}.SU mediates receptor recognition. {ECO:0000250}.TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity). {ECO:0000250}.
Subcellular Localization Virion.
Disease Associations
Tissue Specificity Expressed at higher level in adrenal, sebaceous glands and placenta. Expressed at lower level in bone marrow, brain, breast, colon, heart, kidney, liver, lung, ovary, PBL, prostate, skin, spleen, testis, thymus, thyroid, trachea. {ECO:0000269PubMed:12970426}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0019031 viral envelope
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q14264
PhosphoSite PhosphoSite-Q14264
TrEMBL
UniProt Splice Variant
Entrez Gene 2086
UniGene Hs.707660
RefSeq NP_001007254
HUGO HGNC:3454
OMIM 131170
CCDS CCDS47595
HPRD 15919
IMGT
EMBL AC073210 M12140
GenPept AAA88027

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca