InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CXCL2

Summary

InnateDB Gene

IDBG-24257.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CXCL2

Gene Name

chemokine (C-X-C motif) ligand 2

Synonyms

CINC-2a; GRO2; GROb; MGSA-b; MIP-2a; MIP2; MIP2A; SCYB2

Species

Homo sapiens

Ensembl Gene

ENSG00000081041

Encoded Proteins

IDBP-478241

chemokine (C-X-C motif) ligand 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21757770

CXCL2 is a chemokine secreted by kidney dendritic cells to recruit neutrophils to sites of uropathogenic bacterial infection. (Demonstrated in mouse)

PMID 25005359

Secreted CCNA2 (CCN1) promotes anti-inflammatory cytokine IL10 release from epithelial cells via integrin αVβ6-PKC, and this subsequently suppresses TNF, CXCL2 and neutrophil infiltration in the lungs.

InnateDB Annotation from Orthologs

Summary

PMID 25595775

[Mus musculus] Defb1 is important for the control of early mucosal Candida infection and plays a critical role in the induction of innate inflammatory mediators including, Il1b, Il6, Cxcl1, Il17a, and Il17f.

Entrez Gene

Summary

This antimicrobial gene is part of a chemokine superfamily that encodes secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CXC subfamily, is expressed at sites of inflammation and may suppress hematopoietic progenitor cell proliferation. [provided by RefSeq, Sep 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:74097035-74099293

Strand

Reverse strand

Band

q13.3

Transcripts

ENST00000296031
ENST00000508487	ENSP00000427279
ENST00000510048

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	11 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008009	chemokine activity

Biological Process

GO:0002237	response to molecule of bacterial origin
GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0045087	innate immune response (InnateDB)
GO:0060326	cell chemotaxis

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000029380

View Gene Order

Pathways

NETPATH

REACTOME

REACT_19231

G alpha (i) signalling events pathway

REACT_15344

Chemokine receptors bind chemokines pathway

REACT_14819

Peptide ligand-binding receptors pathway

REACT_14828

Class A/1 (Rhodopsin-like receptors) pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_21340

GPCR ligand binding pathway

KEGG

hsa04060

Cytokine-cytokine receptor interaction pathway

hsa04062

Chemokine signaling pathway pathway

hsa04621

NOD-like receptor signaling pathway pathway

INOH

PID NCI

Cross-References

SwissProt

P19875

TrEMBL

A0A024RDD9 Q6LD33

UniProt Splice Variant

Entrez Gene

2920

UniGene

Hs.75765

RefSeq

NM_002089

HUGO

HGNC:4603

OMIM

139110

CCDS

CCDS34008

HPRD

IMGT

EMBL

AF043340 BC015753 CH471057 CR542171 M36820 M57731 U03019 X53799

GenPept

AAA03453 AAA63182 AAA63183 AAC03540 AAH15753 CAA37808 CAG46968 EAX05700 EAX05701

RNA Seq Atlas

2920