InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CXCL2

Summary

InnateDB Protein

IDBP-478241.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CXCL2

Protein Name

chemokine (C-X-C motif) ligand 2

Synonyms

CINC-2a; GRO2; GROb; MGSA-b; MIP-2a; MIP2; MIP2A; SCYB2;

Species

Homo sapiens

Ensembl Protein

ENSP00000427279

InnateDB Gene

IDBG-24257 (CXCL2)

Protein Structure

UniProt Annotation

Function

Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity. {ECO:0000269PubMed:10725737}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	11 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008009	chemokine activity

Biological Process

GO:0002237	response to molecule of bacterial origin
GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0045087	innate immune response (InnateDB)
GO:0060326	cell chemotaxis