Version 5.4
Homo sapiens Gene: MTHFD2L
Summary
InnateDB Gene IDBG-24298.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MTHFD2L
Gene Name methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000163738
Encoded Proteins
IDBP-24300
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
IDBP-24302
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
IDBP-238914
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
IDBP-371505
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
IDBP-371509
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
IDBP-371512
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
IDBP-371514
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 4:74114174-74303099
Strand Forward strand
Band q13.3
Transcripts
ENST00000325278 ENSP00000321984
ENST00000359107 ENSP00000352012
ENST00000395759 ENSP00000379108
ENST00000429519 ENSP00000391327
ENST00000429335 ENSP00000409391
ENST00000433372 ENSP00000405692
ENST00000423607 ENSP00000387614
ENST00000490698
ENST00000475291
ENST00000461101
ENST00000484725
ENST00000492183
ENST00000461856
ENST00000465255
ENST00000490128
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004477 methenyltetrahydrofolate cyclohydrolase activity
GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity
GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity
Biological Process
GO:0000105 histidine biosynthetic process
GO:0006164 purine nucleotide biosynthetic process
GO:0006730 one-carbon metabolic process
GO:0009086 methionine biosynthetic process
GO:0009396 folic acid-containing compound biosynthetic process
GO:0035999 tetrahydrofolate interconversion
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029376
View Gene Order
ENSBTAG00000043960
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00670
One carbon pool by folate pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.734306 Hs.740700 Hs.740707
RefSeq NM_001144978
HUGO
OMIM
CCDS CCDS47075
HPRD 17608
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca