Homo sapiens Protein: MTHFD2L
Summary
InnateDB Protein IDBP-238914.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MTHFD2L
Protein Name methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000379108
InnateDB Gene IDBG-24298 (MTHFD2L)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Mitochondrion inner membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Matrix side {ECO:0000250}.
Disease Associations
Tissue Specificity Isoform 1, isoform 4 and isoform 5 are expressed in brain and placenta. {ECO:0000269PubMed:21163947}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004477 methenyltetrahydrofolate cyclohydrolase activity
GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity
GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity
Biological Process
GO:0000105 histidine biosynthetic process
GO:0006164 purine nucleotide biosynthetic process
GO:0006730 one-carbon metabolic process
GO:0009086 methionine biosynthetic process
GO:0009396 folic acid-containing compound biosynthetic process
GO:0035999 tetrahydrofolate interconversion
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
Protein Structure and Domains
PDB ID
InterPro IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase
IPR020630 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
IPR020631 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
PFAM PF00763
PF02882
PRINTS PR00085
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H903
PhosphoSite PhosphoSite-Q9H903
TrEMBL F8W7P9
UniProt Splice Variant
Entrez Gene 441024
UniGene Hs.740707
RefSeq NP_001138450
HUGO HGNC:31865
OMIM 614047
CCDS CCDS47075
HPRD 17608
IMGT
EMBL AC093677 AC097470 AK023167 AX794779 BC032771 BC065771 CH471057
GenPept AAH32771 AAH65771 BAB14441 EAX05702 EAX05704 EAX05705 EAX05706