Version 5.4
Homo sapiens Gene: MXD3
Summary
InnateDB Gene IDBG-243286.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MXD3
Gene Name MAX dimerization protein 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000213347
Encoded Proteins
IDBP-382012
MAX dimerization protein 3
IDBP-382014
MAX dimerization protein 3
IDBP-382015
MAX dimerization protein 3
IDBP-480118
MAX dimerization protein 3
IDBP-483242
MAX dimerization protein 3
IDBP-473628
MAX dimerization protein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the Myc superfamily of basic helix-loop-helix leucine zipper transcriptional regulators. The encoded protein forms a heterodimer with the cofactor MAX which binds specific E-box DNA motifs in the promoters of target genes and regulates their transcription. Disruption of the MAX-MXD3 complex is associated with uncontrolled cell proliferation and tumorigenesis. Transcript variants of this gene encoding different isoforms have been described.[provided by RefSeq, Dec 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:177301461-177312757
Strand Reverse strand
Band q35.3
Transcripts
ENST00000427908 ENSP00000416921
ENST00000423571 ENSP00000389716
ENST00000439742 ENSP00000401867
ENST00000503473
ENST00000509339
ENST00000503782
ENST00000513063 ENSP00000421463
ENST00000513169 ENSP00000427104
ENST00000502529 ENSP00000425029
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046983 protein dimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021485
View Gene Order
ENSBTAG00000005010
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.743332
RefSeq NM_001142935 NM_031300
HUGO
OMIM
CCDS CCDS4416 CCDS47347
HPRD 14791
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca