Version 5.4
Homo sapiens Protein: MXD3
Summary
InnateDB Protein IDBP-382012.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MXD3
Protein Name MAX dimerization protein 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000416921
InnateDB Gene IDBG-243286 (MXD3)
Protein Structure
UniProt Annotation
Function Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00981}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0046983 protein dimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
PFAM PF00010
PRINTS
PIRSF
SMART SM00353
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BW11
PhosphoSite PhosphoSite-Q9BW11
TrEMBL D6RD21
UniProt Splice Variant
Entrez Gene 83463
UniGene Hs.743332
RefSeq NP_001136407
HUGO HGNC:14008
OMIM 609450
CCDS CCDS47347
HPRD 14791
IMGT
EMBL AC146507 AF114834 AK057034 AK222579 AL833959 BC000745
GenPept AAH00745 AAP97233 BAB71352 BAD96299 CAD38809

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca