InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SMAD9

Summary

InnateDB Gene

IDBG-24637.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SMAD9

Gene Name

SMAD family member 9

Synonyms

MADH6; MADH9; PPH2; SMAD8; SMAD8A; SMAD8B

Species

Homo sapiens

Ensembl Gene

ENSG00000120693

Encoded Proteins

IDBP-24639

SMAD family member 9

IDBP-24641

SMAD family member 9

IDBP-231039

SMAD family member 9

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the SMAD family, which transduces signals from TGF-beta family members. The encoded protein is activated by bone morphogenetic proteins and interacts with SMAD4. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:36844831-36920765

Strand

Reverse strand

Band

q13.3

Transcripts

ENST00000350148	ENSP00000239885
ENST00000379826	ENSP00000369154
ENST00000399275	ENSP00000382216
ENST00000483941

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 213 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	213 [view]
Protein-Protein	212 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
GO:0046872	metal ion binding

Biological Process

GO:0001657	ureteric bud development
GO:0001666	response to hypoxia
GO:0001880	Mullerian duct regression
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0030509	BMP signaling pathway
GO:0030901	midbrain development
GO:0030902	hindbrain development
GO:0035556	intracellular signal transduction
GO:0045597	positive regulation of cell differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0051216	cartilage development
GO:0060348	bone development
GO:0071407	cellular response to organic cyclic compound

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005667	transcription factor complex
GO:0005737	cytoplasm
GO:0005829	cytosol

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000027796

View Gene Order

Pathways

NETPATH

REACTOME

REACT_12034

Signaling by BMP pathway

REACT_111102

Signal Transduction pathway

KEGG

hsa04350

TGF-beta signaling pathway pathway

INOH

INOH website

TGF-beta signaling pathway

INOH website

BMP2 signaling pathway

PID NCI

bmppathway

BMP receptor signaling

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.123119 Hs.586812

RefSeq

NM_001127217 NM_005905

HUGO

OMIM

CCDS

CCDS45032 CCDS9360

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas