InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Smad9

Summary

InnateDB Gene

IDBG-144967.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Smad9

Gene Name

SMAD family member 9

Synonyms

MADH6; Madh8; Madh9; Smad8

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027796

Encoded Proteins

IDBP-144969

MAD homolog 9 (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of a family of proteins that act as downstream effectors of the bone morphogenetic protein (BMP) signaling pathway. The encoded protein is phosphorylated by BMP receptors, which stimulates its binding to SMAD4 and translocation into the nucleus, where it functions as a regulator of transcription. Activity of this protein is important for embryonic development. Mutation of this gene results in defects in pulmonary vasculature. [provided by RefSeq, Mar 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:54755582-54801257

Strand

Forward strand

Band

Transcripts

ENSMUST00000029371

ENSMUSP00000029371

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 101 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	12 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	101 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0001657	ureteric bud development
GO:0001666	response to hypoxia
GO:0001880	Mullerian duct regression
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0030509	BMP signaling pathway
GO:0030901	midbrain development
GO:0030902	hindbrain development
GO:0045597	positive regulation of cell differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0051216	cartilage development
GO:0060348	bone development
GO:0071407	cellular response to organic cyclic compound