InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TNK1

Summary

InnateDB Gene

IDBG-24740.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNK1

Gene Name

tyrosine kinase, non-receptor, 1

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000174292

Encoded Proteins

IDBP-757906

IDBP-763415

IDBP-809935

tyrosine kinase, non-receptor, 1

IDBP-758337

IDBP-763242

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 24449862

TNK1 is a component of the IFN-JAK-STAT signalling cascade and is a critical antiviral host factor where its abundance is inversely correlated to viral replication and contributes to the hepatocytic response to antiviral treatment.

Entrez Gene

Summary

The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways, mediating cellular proliferation, survival, and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues, thus may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. It plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:7380534-7389774

Strand

Forward strand

Band

p13.1

Transcripts

ENST00000576812	ENSP00000459799
ENST00000576136
ENST00000577009	ENSP00000466590
ENST00000575268
ENST00000576207	ENSP00000475164
ENST00000576716	ENSP00000460146
ENST00000570896	ENSP00000458834
ENST00000574794

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030308	negative regulation of cell growth
GO:0045087	innate immune response (InnateDB)
GO:0046580	negative regulation of Ras protein signal transduction
GO:0046777	protein autophosphorylation

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane
GO:0030054	cell junction

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000001583

View Gene Order

ENSBTAG00000017739

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.203420 Hs.739114

RefSeq

NM_001251902 NM_003985

HUGO

OMIM

CCDS

CCDS45602 CCDS58510

HPRD

09730

IMGT

EMBL

GenPept

RNA Seq Atlas