InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TNK1

Summary

InnateDB Protein

IDBP-757906.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNK1

Protein Name

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000459799

InnateDB Gene

IDBG-24740 (TNK1)

Protein Structure

UniProt Annotation

Function

Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction. {ECO:0000269PubMed:10873601, ECO:0000269PubMed:18974114}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:10873601}. Membrane {ECO:0000269PubMed:10873601}; Peripheral membrane protein {ECO:0000269PubMed:10873601}.

Disease Associations

Tissue Specificity

Expressed in all umbilical cord blood, bone marrow and adult blood cell sub-populations and in several leukemia cell lines. Highly expressed in fetal blood, brain, lung, liver and kidney. Detected at lower levels in adult prostate, testis, ovary, small intestine and colon. Not expressed in adult lung, liver, kidney or brain. {ECO:0000269PubMed:10873601, ECO:0000269PubMed:8632913}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030308	negative regulation of cell growth
GO:0046580	negative regulation of Ras protein signal transduction
GO:0046777	protein autophosphorylation

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane
GO:0030054	cell junction

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001452 SH3 domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR009060 UBA-like
IPR011009 Protein kinase-like domain
IPR013761 Sterile alpha motif/pointed domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF00018
PF14604

PRINTS

PR00109
PR00452

PIRSF

SMART

SM00326
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt