InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RRM1

Summary

InnateDB Gene

IDBG-24798.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RRM1

Gene Name

ribonucleotide reductase M1

Synonyms

R1; RIR1; RR1

Species

Homo sapiens

Ensembl Gene

ENSG00000167325

Encoded Proteins

IDBP-24800

ribonucleotide reductase M1

IDBP-588041

ribonucleotide reductase M1

IDBP-595337

ribonucleotide reductase M1

IDBP-600333

ribonucleotide reductase M1

IDBP-599581

ribonucleotide reductase M1

IDBP-587887

ribonucleotide reductase M1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:4094707-4138876

Strand

Forward strand

Band

p15.4

Transcripts

ENST00000300738	ENSP00000300738
ENST00000532710
ENST00000532170	ENSP00000435656
ENST00000526865
ENST00000533349	ENSP00000434069
ENST00000526350
ENST00000530368
ENST00000528442	ENSP00000432555
ENST00000534285	ENSP00000431464
ENST00000533495	ENSP00000436377
ENST00000526304
ENST00000528470
ENST00000531591
ENST00000529109

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	36 [view]
Protein-Protein	30 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0017076	purine nucleotide binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0006206	pyrimidine nucleobase metabolic process
GO:0006260	DNA replication
GO:0008584	male gonad development
GO:0009263	deoxyribonucleotide biosynthetic process
GO:0010212	response to ionizing radiation
GO:0015949	nucleobase-containing small molecule interconversion
GO:0021846	cell proliferation in forebrain
GO:0044281	small molecule metabolic process
GO:0051259	protein oligomerization
GO:0051290	protein heterotetramerization
GO:0055086	nucleobase-containing small molecule metabolic process
GO:0055114	oxidation-reduction process
GO:0060041	retina development in camera-type eye

Cellular Component

GO:0005635	nuclear envelope
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005971	ribonucleoside-diphosphate reductase complex
GO:0042995	cell projection
GO:0043025	neuronal cell body
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000030978

View Gene Order

ENSBTAG00000013111

Not yet available

Pathways

NETPATH

REACTOME

REACT_21330

Synthesis and interconversion of nucleotide di- and triphosphates pathway

REACT_1698

Metabolism of nucleotides pathway

REACT_111217

Metabolism pathway

KEGG

hsa00240

Pyrimidine metabolism pathway

hsa00230

Purine metabolism pathway

hsa00480

Glutathione metabolism pathway

INOH

INOH website

Purine nucleotides nucleosides metabolism pathway

INOH website

Pyrimidine nucleotides nucleosides metabolism pathway

PID NCI

e2f_pathway

E2F transcription factor network

Cross-References

SwissProt

P23921

TrEMBL

B4DNN4 E9PD78 E9PL69 F5H861

UniProt Splice Variant

Entrez Gene

6240

UniGene

Hs.445705 Hs.609606

RefSeq

NM_001033

HUGO

HGNC:10451

OMIM

180410

CCDS

CCDS7750

HPRD

01588

IMGT

EMBL

AC015689 AF107045 AK297988 BC006498 L10342 X59543 X59617

GenPept

AAD37491 AAH06498 BAG60296 CAA42118 CAA42180

RNA Seq Atlas

6240