InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: RRM1

Summary

InnateDB Gene

IDBG-634697.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RRM1

Gene Name

ribonucleoside-diphosphate reductase large subunit

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000013111

Encoded Proteins

IDBP-686487

ribonucleoside-diphosphate reductase M1 chain

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167325:
This gene encodes one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:51801715-51843018

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000017428

ENSBTAP00000017428

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016491	oxidoreductase activity
GO:0017076	purine nucleotide binding

Biological Process

GO:0006260	DNA replication
GO:0009263	deoxyribonucleotide biosynthetic process
GO:0051259	protein oligomerization
GO:0051290	protein heterotetramerization
GO:0055114	oxidation-reduction process