Version 5.4
Homo sapiens Gene: CROT
Summary
InnateDB Gene IDBG-24917.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CROT
Gene Name carnitine O-octanoyltransferase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000005469
Encoded Proteins
IDBP-24919
carnitine O-octanoyltransferase
IDBP-380896
carnitine O-octanoyltransferase
IDBP-380899
carnitine O-octanoyltransferase
IDBP-380900
carnitine O-octanoyltransferase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the carnitine/choline acetyltransferase family. The encoded protein converts 4,8-dimethylnonanoyl-CoA to its corresponding carnitine ester. This transesterification occurs in the peroxisome and is necessary for transport of medium- and long- chain acyl-CoA molecules out of the peroxisome to the cytosol and mitochondria. The protein thus plays a role in lipid metabolism and fatty acid beta-oxidation. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jan 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:87345681-87399795
Strand Forward strand
Band q21.12
Transcripts
ENST00000331536 ENSP00000331981
ENST00000419147 ENSP00000413575
ENST00000412227 ENSP00000404867
ENST00000442291 ENSP00000411983
ENST00000488850
ENST00000469785
ENST00000479014
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0008458 carnitine O-octanoyltransferase activity
GO:0016746 transferase activity, transferring acyl groups
Biological Process
GO:0006091 generation of precursor metabolites and energy
GO:0006631 fatty acid metabolic process
GO:0006635 fatty acid beta-oxidation
GO:0008152 metabolic process
GO:0009437 carnitine metabolic process
GO:0015908 fatty acid transport
GO:0015936 coenzyme A metabolic process
GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0051791 medium-chain fatty acid metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005777 peroxisome
GO:0005782 peroxisomal matrix
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000003623
View Gene Order
ENSBTAG00000021535
Not yet available
Pathways
NETPATH
REACTOME
REACT_17017
Beta-oxidation of pristanoyl-CoA pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_16957
Peroxisomal lipid metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa04146
Peroxisome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.125039
RefSeq NM_001143935 NM_001243745 NM_021151 XM_006716031
HUGO
OMIM
CCDS CCDS47634 CCDS5604 CCDS59062
HPRD 12081
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca