InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FAR2

Summary

InnateDB Gene

IDBG-25076.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FAR2

Gene Name

fatty acyl CoA reductase 2

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000064763

Encoded Proteins

IDBP-25078

fatty acyl CoA reductase 2

IDBP-584844

fatty acyl CoA reductase 2

IDBP-591074

fatty acyl CoA reductase 2

IDBP-601013

fatty acyl CoA reductase 2

IDBP-602988

fatty acyl CoA reductase 2

IDBP-602415

fatty acyl CoA reductase 2

IDBP-585516

fatty acyl CoA reductase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene belongs to the short chain dehydrogenase/reductase superfamily. It encodes a reductase enzyme involved in the first step of wax biosynthesis wherein fatty acids are converted to fatty alcohols. The encoded peroxisomal protein utilizes saturated fatty acids of 16 or 18 carbons as preferred substrates. Alternatively spliced transcript variants have been observed for this gene. Related pseudogenes have been identified on chromosomes 2, 14 and 22. [provided by RefSeq, Nov 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:29149103-29340980

Strand

Forward strand

Band

p11.22

Transcripts

ENST00000182377	ENSP00000182377
ENST00000551451	ENSP00000450117
ENST00000536681	ENSP00000443291
ENST00000549080
ENST00000547411
ENST00000550541
ENST00000547116	ENSP00000449349
ENST00000552137	ENSP00000449436
ENST00000551193	ENSP00000449187
ENST00000547759	ENSP00000447467

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0050062	long-chain-fatty-acyl-CoA reductase activity
GO:0050662	coenzyme binding
GO:0051287	NAD binding
GO:0080019	fatty-acyl-CoA reductase (alcohol-forming) activity

Biological Process

GO:0006694	steroid biosynthetic process
GO:0008611	ether lipid biosynthetic process
GO:0009058	biosynthetic process
GO:0035336	long-chain fatty-acyl-CoA metabolic process
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005777	peroxisome
GO:0005778	peroxisomal membrane
GO:0005782	peroxisomal matrix
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000030303

View Gene Order

ENSBTAG00000011095

Not yet available

Pathways

NETPATH

REACTOME

REACT_1407

Plasmalogen biosynthesis pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_16957

Peroxisomal lipid metabolism pathway

REACT_111217

Metabolism pathway

KEGG

hsa04146

Peroxisome pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

F8VPF2

UniProt Splice Variant

Entrez Gene

55711

UniGene

Hs.298851 Hs.684482

RefSeq

NM_001271783 NM_001271784 NM_018099

HUGO

HGNC:25531

OMIM

CCDS

CCDS61084 CCDS8717

HPRD

14723

IMGT

EMBL

AC009318 AC012150

GenPept

RNA Seq Atlas

55711