InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CXCL11

Summary

InnateDB Gene

IDBG-25238.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CXCL11

Gene Name

chemokine (C-X-C motif) ligand 11

Synonyms

b-R1; H174; I-TAC; IP-9; IP9; SCYB11; SCYB9B

Species

Homo sapiens

Ensembl Gene

ENSG00000169248

Encoded Proteins

IDBP-25240

chemokine (C-X-C motif) ligand 11

IDBP-481613

chemokine (C-X-C motif) ligand 11

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21124994

CXCL11 exert direct antimicrobial effects in vitro against Bacillus anthracis spore and bacilli in a receptor-independent manner and contributes to pulmonary innate immunity. (Demonstrated in murine model)

Entrez Gene

Summary

Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC. This gene is a CXC member of the chemokine superfamily. Its encoded protein induces a chemotactic response in activated T-cells and is the dominant ligand for CXC receptor-3. The gene encoding this protein contains 4 exons and at least three polyadenylation signals which might reflect cell-specific regulation of expression. IFN-gamma is a potent inducer of transcription of this gene. [provided by RefSeq, Jul 2008]
Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC. This antimicrobial gene is a CXC member of the chemokine superfamily. Its encoded protein induces a chemotactic response in activated T-cells and is the dominant ligand for CXC receptor-3. The gene encoding this protein contains 4 exons and at least three polyadenylation signals which might reflect cell-specific regulation of expression. IFN-gamma is a potent inducer of transcription of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:76033682-76041415

Strand

Reverse strand

Band

q21.1

Transcripts

ENST00000306621	ENSP00000306884
ENST00000503860	ENSP00000425819

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	9 [view]
Protein-DNA	7 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008009	chemokine activity
GO:0008201	heparin binding
GO:0048248	CXCR3 chemokine receptor binding

Biological Process

GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0010818	T cell chemotaxis
GO:0030816	positive regulation of cAMP metabolic process
GO:0042127	regulation of cell proliferation
GO:0043950	positive regulation of cAMP-mediated signaling
GO:0045087	innate immune response (InnateDB)
GO:0051281	positive regulation of release of sequestered calcium ion into cytosol
GO:0070098	chemokine-mediated signaling pathway