InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CXCL11

Summary

InnateDB Protein

IDBP-481613.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CXCL11

Protein Name

chemokine (C-X-C motif) ligand 11

Synonyms

b-R1; H174; I-TAC; IP-9; IP9; SCYB11; SCYB9B;

Species

Homo sapiens

Ensembl Protein

ENSP00000425819

InnateDB Gene

IDBG-25238 (CXCL11)

Protein Structure

UniProt Annotation

Function

Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

High levels in peripheral blood leukocytes, pancreas and liver astrocytes. Moderate levels in thymus, spleen and lung. Low levels in placenta, prostate and small intestine. Also found in epidermal basal layer keratinocytes in skin disorders.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	9 [view]
Protein-DNA	7 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008009	chemokine activity
GO:0008201	heparin binding
GO:0048248	CXCR3 chemokine receptor binding

Biological Process

GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0010818	T cell chemotaxis
GO:0030816	positive regulation of cAMP metabolic process
GO:0042127	regulation of cell proliferation
GO:0043950	positive regulation of cAMP-mediated signaling
GO:0045087	innate immune response (InnateDB)
GO:0051281	positive regulation of release of sequestered calcium ion into cytosol
GO:0070098	chemokine-mediated signaling pathway