Version 5.4
Homo sapiens Gene: HIRIP3
Summary
InnateDB Gene IDBG-25278.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HIRIP3
Gene Name HIRA interacting protein 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000149929
Encoded Proteins
IDBP-25280
HIRA interacting protein 3
IDBP-752196
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The HIRA protein shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae. The structural features of the HIRA protein suggest that it may function as part of a multiprotein complex. Several cDNAs encoding HIRA-interacting proteins, or HIRIPs, have been identified. In vitro, the protein encoded by this gene binds HIRA, as well as H2B and H3 core histones, indicating that a complex containing HIRA-HIRIP3 could function in some aspects of chromatin and histone metabolism. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:29992321-29996436
Strand Reverse strand
Band p11.2
Transcripts
ENST00000279392 ENSP00000279392
ENST00000563053
ENST00000568880
ENST00000564026 ENSP00000456824
ENST00000566471
ENST00000565996
ENST00000563680
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 31 [view]
Protein-Protein 30 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006333 chromatin assembly or disassembly
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000042606
View Gene Order
ENSBTAG00000005028
Not yet available
Cross-References
SwissProt Q9BW71
TrEMBL B3KQL0
UniProt Splice Variant
Entrez Gene 8479
UniGene Hs.567370
RefSeq NM_003609 NM_001197323
HUGO HGNC:4917
OMIM 603365
CCDS CCDS10664 CCDS58449
HPRD 04531
IMGT
EMBL AC093512 AJ223349 AJ223350 AJ223351 AK075145 BC000588 BX393533
GenPept AAH00588 BAG52072 CAA11273 CAA11274 CAA11275
RNA Seq Atlas 8479

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca