Version 5.4
Homo sapiens Protein: HIRIP3
Summary
InnateDB Protein IDBP-25280.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HIRIP3
Protein Name HIRA interacting protein 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000279392
InnateDB Gene IDBG-25278 (HIRIP3)
Protein Structure
UniProt Annotation
Function May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones. {ECO:0000269PubMed:9710638}.
Subcellular Localization Nucleus {ECO:0000269PubMed:17391060}. Note=Nuclear throughout the cell cycle and is excluded from condensed chromatin during mitosis.
Disease Associations
Tissue Specificity Widely expressed. Isoform 1 is predominant in skeletal muscle. Isoform 2 is predominant in liver and heart. {ECO:0000269PubMed:9710638}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 31 [view]
Protein-Protein 30 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006333 chromatin assembly or disassembly
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR019098 Histone chaperone domain CHZ
PFAM PF09649
PRINTS
PIRSF
SMART SM01082
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BW71
PhosphoSite PhosphoSite-Q9BW71
TrEMBL B3KQL0
UniProt Splice Variant
Entrez Gene 8479
UniGene Hs.567370
RefSeq NP_003600
HUGO HGNC:4917
OMIM 603365
CCDS CCDS10664
HPRD 04531
IMGT
EMBL AC093512 AJ223349 AJ223350 AJ223351 AK075145 BC000588 BX393533
GenPept AAH00588 BAG52072 CAA11273 CAA11274 CAA11275

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca