Version 5.4
| Mus musculus Gene: Col4a3 | |||||||||||||||||
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| Summary | |||||||||||||||||
| InnateDB Gene | IDBG-253830.6 | ||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||
| Gene Symbol | Col4a3 | ||||||||||||||||
| Gene Name | collagen, type IV, alpha 3 | ||||||||||||||||
| Synonyms | [a]3(IV); alpha3(IV) | ||||||||||||||||
| Species | Mus musculus | ||||||||||||||||
| Ensembl Gene | ENSMUSG00000079465 | ||||||||||||||||
| Encoded Proteins |
collagen, type IV, alpha 3
collagen, type IV, alpha 3
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| Protein Structure | |||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||
| Entrez Gene | |||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169031:
Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. This gene is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal region. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. [provided by RefSeq, Jun 2010] |
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| Gene Information | |||||||||||||||||
| Type | Protein coding | ||||||||||||||||
| Genomic Location | Chromosome 1:82586921-82722059 | ||||||||||||||||
| Strand | Forward strand | ||||||||||||||||
| Band | C5 | ||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||
| NETPATH | |||||||||||||||||
| REACTOME |
Collagen formation pathway
Assembly of collagen fibrils and other multimeric structures pathway
NCAM1 interactions pathway
Collagen biosynthesis and modifying enzymes pathway
Anchoring fibril formation pathway
Extracellular matrix organization pathway
Laminin interactions pathway
Axon guidance pathway
Integrin cell surface interactions pathway
Signaling by PDGF pathway
Developmental Biology pathway
ECM proteoglycans pathway
Non-integrin membrane-ECM interactions pathway
Signal Transduction pathway
NCAM signaling for neurite out-growth pathway
Degradation of the extracellular matrix pathway
Collagen degradation pathway
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| KEGG |
ECM-receptor interaction pathway
Small cell lung cancer pathway
Focal adhesion pathway
Pathways in cancer pathway
Amoebiasis pathway
Protein digestion and absorption pathway
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| INOH | |||||||||||||||||
| PID NCI | |||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||
| NETPATH | |||||||||||||||||
| REACTOME |
Integrin cell surface interactions pathway
Signaling by PDGF pathway
Anchoring fibril formation pathway
Assembly of collagen fibrils and other multimeric structures pathway
Collagen biosynthesis and modifying enzymes pathway
Collagen degradation pathway
NCAM1 interactions pathway
NCAM signaling for neurite out-growth pathway
Developmental Biology pathway
Extracellular matrix organization pathway
Degradation of the extracellular matrix pathway
Axon guidance pathway
Signal Transduction pathway
ECM proteoglycans pathway
Non-integrin membrane-ECM interactions pathway
Laminin interactions pathway
Collagen formation pathway
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| KEGG |
ECM-receptor interaction pathway
Small cell lung cancer pathway
Focal adhesion pathway
Pathways in cancer pathway
Amoebiasis pathway
Protein digestion and absorption pathway
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| INOH |
Integrin signaling pathway pathway
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| PID NCI |
Integrins in angiogenesis
Beta3 integrin cell surface interactions
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| Cross-References | |||||||||||||||||
| SwissProt | |||||||||||||||||
| TrEMBL | F6RIS8 | ||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||
| Entrez Gene | 12828 | ||||||||||||||||
| UniGene | Mm.389135 Mm.416477 | ||||||||||||||||
| RefSeq | NM_007734 | ||||||||||||||||
| OMIM | |||||||||||||||||
| CCDS | CCDS35631 | ||||||||||||||||
| HPRD | |||||||||||||||||
| IMGT | |||||||||||||||||
| MGI ID | MGI:104688 | ||||||||||||||||
| MGI Symbol | Col4a3 | ||||||||||||||||
| EMBL | AC123746 AC138214 | ||||||||||||||||
| GenPept | |||||||||||||||||
| RNA Seq Atlas | 12828 | ||||||||||||||||