Version 5.4
Mus musculus Gene: Gbp6
Summary
InnateDB Gene IDBG-255448.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gbp6
Gene Name guanylate binding protein 6
Synonyms AI595338; Mpa2l
Species Mus musculus
Ensembl Gene ENSMUSG00000079362
Encoded Proteins
IDBP-185860
guanylate binding protein 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21551061
Gbp6 is an IFN gamma-inducible gene that confers cell-autonomous immunity to listerial or mycobacterial infection within macrophages. Gbp6 interacts with host defense proteins, including phagocyte oxidase, antimicrobial peptides and autophagy effectors, to kill intracellular bacteria.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 5:105215699-105293699
Strand Reverse strand
Band E5
Transcripts
ENSMUST00000050011 ENSMUSP00000062528
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0006184 GTP catabolic process
GO:0006955 immune response
GO:0035458 cellular response to interferon-beta
GO:0042742 defense response to bacterium
GO:0042832 defense response to protozoan
GO:0044406 adhesion of symbiont to host
GO:0045087 innate immune response (InnateDB)
GO:0050830 defense response to Gram-positive bacterium
GO:0071222 cellular response to lipopolysaccharide
GO:0071346 cellular response to interferon-gamma
Cellular Component
GO:0020005 symbiont-containing vacuole membrane
GO:0031410 cytoplasmic vesicle
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.275893
RefSeq NM_001039646 NM_194336 XM_006534687 XM_006534688 XM_006534689 XM_006534690 XM_006534691
OMIM
CCDS CCDS19492 CCDS51581
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca