Version 5.4
Homo sapiens Gene: CDK14
Summary
InnateDB Gene IDBG-25876.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDK14
Gene Name cyclin-dependent kinase 14
Synonyms PFTAIRE1; PFTK1
Species Homo sapiens
Ensembl Gene ENSG00000058091
Encoded Proteins
IDBP-25880
cyclin-dependent kinase 14
IDBP-25882
cyclin-dependent kinase 14
IDBP-295465
cyclin-dependent kinase 14
IDBP-381405
cyclin-dependent kinase 14
IDBP-381408
cyclin-dependent kinase 14
IDBP-381409
cyclin-dependent kinase 14
IDBP-381413
cyclin-dependent kinase 14
IDBP-381433
cyclin-dependent kinase 14
IDBP-381443
cyclin-dependent kinase 14
IDBP-381450
cyclin-dependent kinase 14
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary PFTK1 is a member of the CDC2 (MIM 116940)-related protein kinase family (Yang and Chen, 2001 [PubMed 11313143]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:90466424-91210590
Strand Forward strand
Band q21.13
Transcripts
ENST00000265741 ENSP00000265741
ENST00000380050 ENSP00000369390
ENST00000406263 ENSP00000385034
ENST00000449528 ENSP00000393616
ENST00000430760 ENSP00000394570
ENST00000456689 ENSP00000406848
ENST00000446224 ENSP00000410770
ENST00000446790 ENSP00000401603
ENST00000436577 ENSP00000398936
ENST00000431029 ENSP00000387794
ENST00000484035
ENST00000496279
ENST00000478540
ENST00000487145
ENST00000460493
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 23 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0030332 cyclin binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0006468 protein phosphorylation
GO:0016055 Wnt signaling pathway
GO:0051301 cell division
GO:0051726 regulation of cell cycle
GO:0060828 regulation of canonical Wnt signaling pathway
Cellular Component
GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000028926
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.258576 Hs.629140 Hs.740065
RefSeq NM_001287135 NM_001287136 NM_001287137 NM_012395 XM_005250435 XM_005250436 XM_005250438 XM_005250439 XM_006716026
HUGO
OMIM
CCDS CCDS5619 CCDS75626 CCDS75627 CCDS75628
HPRD 15121
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca