Homo sapiens Protein: CDK14 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-25880.7 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | CDK14 | ||||||||||||||||||||||
Protein Name | cyclin-dependent kinase 14 | ||||||||||||||||||||||
Synonyms | PFTAIRE1; PFTK1; | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Protein | ENSP00000265741 | ||||||||||||||||||||||
InnateDB Gene | IDBG-25876 (CDK14) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport. {ECO:0000269PubMed:16461467, ECO:0000269PubMed:17517622, ECO:0000269PubMed:19524571, ECO:0000269PubMed:20059949}. | ||||||||||||||||||||||
Subcellular Localization | Cell membrane; Peripheral membrane protein. Cytoplasm. Nucleus. Note=Recruited to the cell membrane by CCNY. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | Highly expressed in brain, pancreas, kidney, heart, testis and ovary. Also detected at lower levels in other tissues except in spleen and thymus where expression is barely detected. {ECO:0000269PubMed:11313143}. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||
InterPro |
IPR000719
Protein kinase domain IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain IPR011009 Protein kinase-like domain IPR020635 Tyrosine-protein kinase, catalytic domain |
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PFAM |
PF00069
PF07714 |
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PRINTS |
PR00109
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PIRSF | |||||||||||||||||||||||
SMART |
SM00220
SM00219 |
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | O94921 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-O94921 | ||||||||||||||||||||||
TrEMBL | C9JWL6 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 5218 | ||||||||||||||||||||||
UniGene | Hs.740065 | ||||||||||||||||||||||
RefSeq | NP_036527 | ||||||||||||||||||||||
HUGO | HGNC:8883 | ||||||||||||||||||||||
OMIM | 610679 | ||||||||||||||||||||||
CCDS | CCDS5619 | ||||||||||||||||||||||
HPRD | 15121 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AB020641 AC000057 AC000059 AC002065 AC002456 AC002458 AC003076 AC006036 AC017036 AC084381 AF119833 AK289782 AK295086 AK297974 AK316026 BC136476 BC136477 BC152388 BC152436 BC167152 BC167156 CH236949 CH471091 | ||||||||||||||||||||||
GenPept | AAF19245 AAG43234 AAI36477 AAI36478 AAI52389 AAI52437 AAI67152 AAI67156 AAM48566 AAS07411 AAS07412 BAA74857 BAF82471 BAG58127 BAG60284 BAH14397 EAL24162 EAW76873 EAW76874 | ||||||||||||||||||||||