InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: USP14

Summary

InnateDB Gene

IDBG-259.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

USP14

Gene Name

ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)

Synonyms

TGT

Species

Homo sapiens

Ensembl Gene

ENSG00000101557

Encoded Proteins

IDBP-261

ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)

IDBP-263

ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)

IDBP-228677

ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)

IDBP-726168

IDBP-727583

IDBP-727521

IDBP-808979

ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:158383-214629

Strand

Forward strand

Band

p11.32

Transcripts

ENST00000261601	ENSP00000261601
ENST00000383589	ENSP00000373083
ENST00000400266	ENSP00000383125
ENST00000581983	ENSP00000462315
ENST00000580410	ENSP00000463891
ENST00000578786
ENST00000582707	ENSP00000464447
ENST00000583119	ENSP00000473563
ENST00000578942

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 70 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	70 [view]
Protein-Protein	70 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004197	cysteine-type endopeptidase activity
GO:0004221	ubiquitin thiolesterase activity
GO:0004843	ubiquitin-specific protease activity
GO:0004866	endopeptidase inhibitor activity
GO:0005515	protein binding
GO:0008193	tRNA guanylyltransferase activity
GO:0008234	cysteine-type peptidase activity
GO:0036459	ubiquitinyl hydrolase activity
GO:0070628	proteasome binding

Biological Process

GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007268	synaptic transmission
GO:0010951	negative regulation of endopeptidase activity
GO:0016579	protein deubiquitination
GO:0050920	regulation of chemotaxis
GO:0061136	regulation of proteasomal protein catabolic process

Cellular Component

GO:0000502	proteasome complex
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0045202	synapse

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000047879

View Gene Order

ENSBTAG00000019214

Not yet available

Cross-References

SwissProt

P54578

TrEMBL

A6NJA2 B7Z4N8 D3DUG9 J3KS55

UniProt Splice Variant

Entrez Gene

9097

UniGene

Hs.464416 Hs.579511 Hs.597121 Hs.608031 Hs.707058 Hs.717953 Hs.732072

RefSeq

NM_001037334 NM_005151

HUGO

HGNC:12612

OMIM

607274

CCDS

CCDS32780 CCDS32781

HPRD

IMGT

EMBL

AK297605 AP000845 BC003556 BT007183 CH471113 CR976282 U30888

GenPept

AAB60365 AAH03556 AAP35847 BAH12624 EAX01735 EAX01736

RNA Seq Atlas

9097