Version 5.4
Mus musculus Gene: Usp14
Summary
InnateDB Gene IDBG-128322.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Usp14
Gene Name ubiquitin specific peptidase 14
Synonyms 2610005K12Rik; 2610037B11Rik; AW107924; ax; C78769; nmf375
Species Mus musculus
Ensembl Gene ENSMUSG00000047879
Encoded Proteins
IDBP-128324
ubiquitin specific peptidase 14
IDBP-273548
ubiquitin specific peptidase 14
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101557:
This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:9995432-10045119
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000092096 ENSMUSP00000089728
ENSMUST00000116669 ENSMUSP00000112368
ENSMUST00000133594
ENSMUST00000154088
ENSMUST00000128334
ENSMUST00000145929
ENSMUST00000142013
ENSMUST00000150321
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 45 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 45 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004221 ubiquitin thiolesterase activity
GO:0004843 ubiquitin-specific protease activity
GO:0004866 endopeptidase inhibitor activity
GO:0005515 protein binding
GO:0008234 cysteine-type peptidase activity
GO:0036459 ubiquitinyl hydrolase activity
GO:0070628 proteasome binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007268 synaptic transmission
GO:0010951 negative regulation of endopeptidase activity
GO:0016579 protein deubiquitination
GO:0050920 regulation of chemotaxis
GO:0061136 regulation of proteasomal protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0045202 synapse
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000101557
View Gene Order
ENSBTAG00000019214
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.329277 Mm.447089 Mm.486967
RefSeq NM_001038589 NM_021522 XM_006526134 XM_006526135
OMIM
CCDS CCDS37734 CCDS37735
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca