Version 5.4
Homo sapiens Gene: AKAP9
Summary
InnateDB Gene IDBG-25989.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AKAP9
Gene Name A kinase (PRKA) anchor protein (yotiao) 9
Synonyms AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION; LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO
Species Homo sapiens
Ensembl Gene ENSG00000127914
Encoded Proteins
IDBP-25991
A kinase (PRKA) anchor protein (yotiao) 9
IDBP-25993
A kinase (PRKA) anchor protein (yotiao) 9
IDBP-25995
A kinase (PRKA) anchor protein (yotiao) 9
IDBP-241280
A kinase (PRKA) anchor protein (yotiao) 9
IDBP-241282
A kinase (PRKA) anchor protein (yotiao) 9
IDBP-381587
A kinase (PRKA) anchor protein (yotiao) 9
IDBP-381590
A kinase (PRKA) anchor protein (yotiao) 9
IDBP-806980
A kinase (PRKA) anchor protein 9
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternate splicing of this gene results in at least two isoforms that localize to the centrosome and the Golgi apparatus, and interact with numerous signaling proteins from multiple signal transduction pathways. These signaling proteins include type II protein kinase A, serine/threonine kinase protein kinase N, protein phosphatase 1, protein phosphatase 2a, protein kinase C-epsilon and phosphodiesterase 4D3. [provided by RefSeq, Aug 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:91940867-92110673
Strand Forward strand
Band q21.2
Transcripts
ENST00000356239 ENSP00000348573
ENST00000359028 ENSP00000351922
ENST00000358100 ENSP00000350813
ENST00000394564 ENSP00000378065
ENST00000394534 ENSP00000378042
ENST00000438114 ENSP00000391704
ENST00000435423 ENSP00000406937
ENST00000493453
ENST00000484815
ENST00000491695
ENST00000487258
ENST00000487692
ENST00000463118
ENST00000486313
ENST00000493976
ENST00000619023 ENSP00000480807
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 49 [view]
Protein-Protein 46 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0016301 kinase activity
GO:0032947 protein complex scaffold
GO:0044325 ion channel binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0006810 transport
GO:0007165 signal transduction
GO:0007268 synaptic transmission
GO:0007283 spermatogenesis
GO:0016310 phosphorylation
GO:0060009 Sertoli cell development
Cellular Component
GO:0000242 pericentriolar material
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0008076 voltage-gated potassium channel complex
GO:0036064 ciliary basal body
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040407
View Gene Order
ENSBTAG00000007442
Not yet available
Pathways
NETPATH
REACTOME
REACT_160315
Regulation of PLK1 Activity at G2/M Transition pathway
REACT_15364
Loss of Nlp from mitotic centrosomes pathway
REACT_15451
Loss of proteins required for interphase microtubule organization� from the centrosome pathway
REACT_15296
Recruitment of mitotic centrosome proteins and complexes pathway
REACT_20546
Ras activation uopn Ca2+ infux through NMDA receptor pathway
REACT_20568
CREB phosphorylation through the activation of Ras pathway
REACT_20642
CREB phosphorylation through the activation of CaMKII pathway
REACT_20594
Unblocking of NMDA receptor, glutamate binding and activation pathway
REACT_13685
Neuronal System pathway
REACT_20593
Post NMDA receptor activation events pathway
REACT_115566
Cell Cycle pathway
REACT_20563
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
REACT_15479
Centrosome maturation pathway
REACT_2203
G2/M Transition pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_21391
Mitotic G2-G2/M phases pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL H7BYL6
UniProt Splice Variant
Entrez Gene 10142
UniGene Hs.651221
RefSeq NM_005751 NM_147185
HUGO HGNC:379
OMIM 604001
CCDS CCDS5622
HPRD 04921
IMGT
EMBL AC000066 AC000120 AC003086 AC004013
GenPept
RNA Seq Atlas 10142

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca