InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AKAP9

Summary

InnateDB Protein

IDBP-25993.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AKAP9

Protein Name

A kinase (PRKA) anchor protein (yotiao) 9

Synonyms

AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION; LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO;

Species

Homo sapiens

Ensembl Protein

ENSP00000351922

InnateDB Gene

IDBG-25989 (AKAP9)

Protein Structure

UniProt Annotation

Function

Binds to type II regulatory subunits of protein kinase A. Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. May be required to maintain the integrity of the Golgi apparatus. Isoform 4 is associated with the N-methyl-D-aspartate receptor and is specifically found in the neuromuscular junction (NMJ) as well as in neuronal synapses, suggesting a role in the organization of postsynaptic specializations. {ECO:0000269PubMed:15047863}.

Subcellular Localization

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Golgi apparatus. Note=Cytoplasmic in parietal cells.

Disease Associations

Long QT syndrome 11 (LQT11) [MIM:611820]: A heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy. {ECO:0000269PubMed:18093912}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Widely expressed. Isoform 4 is highly expressed in skeletal muscle and in pancreas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	49 [view]
Protein-Protein	46 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0032947	protein complex scaffold
GO:0044325	ion channel binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006810	transport
GO:0007165	signal transduction
GO:0007268	synaptic transmission

Cellular Component

GO:0005794	Golgi apparatus
GO:0005813	centrosome
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0008076	voltage-gated potassium channel complex
GO:0043231	intracellular membrane-bounded organelle