Version 5.4
Homo sapiens Gene: STARD5
Summary
InnateDB Gene IDBG-26097.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STARD5
Gene Name StAR-related lipid transfer (START) domain containing 5
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000172345
Encoded Proteins
IDBP-26099
StAR-related lipid transfer (START) domain containing 5
IDBP-26101
StAR-related lipid transfer (START) domain containing 5
IDBP-602389
StAR-related lipid transfer (START) domain containing 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Cholesterol homeostasis is regulated, at least in part, by sterol regulatory element (SRE)-binding proteins (e.g., SREBP1; MIM 184756) and by liver X receptors (e.g., LXRA; MIM 602423). Upon sterol depletion, LXRs are inactive and SREBPs are cleaved, after which they bind promoter SREs and activate genes involved in cholesterol biosynthesis and uptake. Sterol transport is mediated by vesicles or by soluble protein carriers, such as steroidogenic acute regulatory protein (STAR; MIM 600617). STAR is homologous to a family of proteins containing a 200- to 210-amino acid STAR-related lipid transfer (START) domain, including STARD5 (Soccio et al., 2002 [PubMed 12011452]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:81309053-81324183
Strand Reverse strand
Band q25.1
Transcripts
ENST00000302824 ENSP00000304032
ENST00000325346 ENSP00000317519
ENST00000560723
ENST00000560156 ENSP00000453368
ENST00000559913
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0008289 lipid binding
Biological Process
GO:0006700 C21-steroid hormone biosynthetic process
GO:0006869 lipid transport
GO:0008202 steroid metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000046027
View Gene Order
ENSBTAG00000010964
Not yet available
Pathways
NETPATH
REACTOME
REACT_11038
Pregnenolone biosynthesis pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_11057
Metabolism of steroid hormones and vitamin D pathway
REACT_111217
Metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.513075 Hs.585683
RefSeq NM_181900
HUGO
OMIM
CCDS CCDS10318
HPRD 09517
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca