InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: COL5A3

Summary

InnateDB Gene

IDBG-26167.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

COL5A3

Gene Name

collagen, type V, alpha 3

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000080573

Encoded Proteins

IDBP-26169

collagen, type V, alpha 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. Mutations in this gene are thought to be responsible for the symptoms of a subset of patients with Ehlers-Danlos syndrome type III. Messages of several sizes can be detected in northern blots but sequence information cannot confirm the identity of the shorter messages. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:9959561-10010471

Strand

Reverse strand

Band

p13.2

Transcripts

ENST00000264828	ENSP00000264828
ENST00000461214

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005201	extracellular matrix structural constituent
GO:0005518	collagen binding
GO:0008201	heparin binding
GO:0043394	proteoglycan binding

Biological Process

GO:0007160	cell-matrix adhesion
GO:0007411	axon guidance
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0030199	collagen fibril organization
GO:0030574	collagen catabolic process
GO:0043588	skin development

Cellular Component

GO:0005576	extracellular region
GO:0005581	collagen trimer
GO:0005588	collagen type V
GO:0005788	endoplasmic reticulum lumen
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome