Version 5.4
Mus musculus Gene: Tgtp1
Summary
InnateDB Gene IDBG-262889.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tgtp1
Gene Name T cell specific GTPase 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000078922
Encoded Proteins
IDBP-137871
T-cell specific GTPase 1
IDBP-541909
T-cell specific GTPase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21757726
Tgtp1 is part of the Immunity-Related GTPases (IRGs) family of proteins that are induced by interferon-gamma (Ifng) and play a crucial role in innate resistance to intracellular pathogens. Tgtp1 also influences the localization of Gbp2 by modulating macroautophagy.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 11:48985327-48994172
Strand Reverse strand
Band B1.2
Transcripts
ENSMUST00000068063 ENSMUSP00000069914
ENSMUST00000146439 ENSMUSP00000123089
ENSMUST00000132745
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0003924 GTPase activity
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0016817 hydrolase activity, acting on acid anhydrides
Biological Process
GO:0006184 GTP catabolic process
GO:0006955 immune response
GO:0007049 cell cycle
GO:0007059 chromosome segregation
GO:0008152 metabolic process
GO:0009615 response to virus
GO:0045087 innate immune response (InnateDB)
GO:0051301 cell division
Cellular Component
GO:0005622 intracellular
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.15793
RefSeq NM_011579
OMIM
CCDS CCDS24593
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca