Version 5.4
Mus musculus Gene: Igtp
Summary
InnateDB Gene IDBG-263693.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Igtp
Gene Name interferon gamma induced GTPase
Synonyms AW558444; Irgm3
Species Mus musculus
Ensembl Gene ENSMUSG00000078853
Encoded Proteins
IDBP-176363
interferon gamma induced GTPase
IDBP-176365
interferon gamma induced GTPase
IDBP-625685
interferon gamma induced GTPase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21731484
Igtp is responsible for the IFN-gamma mediated induction of the antimicrobial defence system against Chlamydia trachomatis in mouse. Irgm1/Igtp knockout mice develop high bacterial burden post intrauterine infection, but subsequently clear the infection more efficiently than wt mice due to a compensatory T cell response.
PMID 21757726
Igtp is part of the Immunity-Related GTPases (IRGs) family of proteins that are induced by interferon-gamma (Ifng) and play a crucial role in innate resistance to intracellular pathogens. Igtp also influences the localization of Gbp2 by modulating macroautophagy.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 11:58199556-58207591
Strand Forward strand
Band B1.3
Transcripts
ENSMUST00000035266 ENSMUSP00000047356
ENSMUST00000094169 ENSMUSP00000091721
ENSMUST00000168280 ENSMUSP00000130878
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 3 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0016817 hydrolase activity, acting on acid anhydrides
Biological Process
GO:0006184 GTP catabolic process
GO:0035458 cellular response to interferon-beta
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005829 cytosol
GO:0016020 membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
mmu05145
Toxoplasmosis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.33902 Mm.487666
RefSeq NM_018738
OMIM
CCDS CCDS24725
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca