InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CHD8

Summary

InnateDB Gene

IDBG-2645.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHD8

Gene Name

chromodomain helicase DNA binding protein 8

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000100888

Encoded Proteins

IDBP-229264

chromodomain helicase DNA binding protein 8

IDBP-361108

chromodomain helicase DNA binding protein 8

IDBP-599367

chromodomain helicase DNA binding protein 8

IDBP-583190

chromodomain helicase DNA binding protein 8

IDBP-601788

chromodomain helicase DNA binding protein 8

IDBP-601742

chromodomain helicase DNA binding protein 8

IDBP-585447

chromodomain helicase DNA binding protein 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a DNA helicase that functions as a transcription repressor by remodeling chromatin structure. It binds beta-catenin and negatively regulates Wnt signaling pathway, which plays a pivotal role in vertebrate early development and morphogenesis. Mice lacking this gene exhibit early embryonic death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:21385194-21456126

Strand

Reverse strand

Band

q11.2

Transcripts

ENST00000399982	ENSP00000382863
ENST00000430710	ENSP00000406288
ENST00000557727
ENST00000557364	ENSP00000451601
ENST00000553870	ENSP00000451071
ENST00000555301
ENST00000557329
ENST00000555962
ENST00000555935	ENSP00000451442
ENST00000554384
ENST00000553283	ENSP00000450860
ENST00000553622	ENSP00000450957
ENST00000556833
ENST00000553651

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	39 [view]
Protein-Protein	36 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002039	p53 binding
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003678	DNA helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008013	beta-catenin binding
GO:0008094	DNA-dependent ATPase activity
GO:0016787	hydrolase activity
GO:0016817	hydrolase activity, acting on acid anhydrides
GO:0035064	methylated histone binding
GO:0042393	histone binding
GO:0070016	armadillo repeat domain binding

Biological Process

GO:0001701	in utero embryonic development
GO:0006200	ATP catabolic process
GO:0006351	transcription, DNA-templated
GO:0030178	negative regulation of Wnt signaling pathway
GO:0032508	DNA duplex unwinding
GO:0043044	ATP-dependent chromatin remodeling
GO:0043066	negative regulation of apoptotic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0045945	positive regulation of transcription from RNA polymerase III promoter
GO:0060070	canonical Wnt signaling pathway
GO:2000270	negative regulation of fibroblast apoptotic process